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posaconazole  (Enamine Ltd)


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    Structured Review

    Enamine Ltd posaconazole
    Posaconazole, supplied by Enamine Ltd, used in various techniques. Bioz Stars score: 94/100, based on 24 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/posaconazole/Posaconazole/custom%40en300-19769273%4010%2E64898%2F2026%2E07%2E30%2E741933
    Average 94 stars, based on 24 article reviews
    posaconazole - by Bioz Stars, 2026-10
    94/100 stars

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    Related Articles

    Activation Assay:

    Article Title: Assessment of the potential risk of oteseconazole and two other tetrazole antifungals to inhibit adrenal steroidogenesis and peripheral metabolism of corticosteroids
    Article Snippet: ymes. In addition, the tetrazoles were subjected to a cell-free 11β-HSD2 activity assay to assess a potential risk of causing pseudohyperaldosteronism. Prochloraz (CAS: 67747-09-5), posaconazole (CAS: 171228-49-2), itraconazole (CAS: 84625-61-6), ketoconazole (CAS: 65277-42-1), fluconazole (CAS: 86386-73-4), voriconazole (CAS: 137234-62-9), isavuconazole (CAS: 241479-67-4), bisphenol A (CAS: 80-05-

    Cell Culture:

    Article Title: Assessment of the potential risk of oteseconazole and two other tetrazole antifungals to inhibit adrenal steroidogenesis and peripheral metabolism of corticosteroids
    Article Snippet: ymes. In addition, the tetrazoles were subjected to a cell-free 11β-HSD2 activity assay to assess a potential risk of causing pseudohyperaldosteronism. Prochloraz (CAS: 67747-09-5), posaconazole (CAS: 171228-49-2), itraconazole (CAS: 84625-61-6), ketoconazole (CAS: 65277-42-1), fluconazole (CAS: 86386-73-4), voriconazole (CAS: 137234-62-9), isavuconazole (CAS: 241479-67-4), bisphenol A (CAS: 80-05-

    Concentration Assay:

    Article Title: Assessment of the potential risk of oteseconazole and two other tetrazole antifungals to inhibit adrenal steroidogenesis and peripheral metabolism of corticosteroids
    Article Snippet: ymes. In addition, the tetrazoles were subjected to a cell-free 11β-HSD2 activity assay to assess a potential risk of causing pseudohyperaldosteronism. Prochloraz (CAS: 67747-09-5), posaconazole (CAS: 171228-49-2), itraconazole (CAS: 84625-61-6), ketoconazole (CAS: 65277-42-1), fluconazole (CAS: 86386-73-4), voriconazole (CAS: 137234-62-9), isavuconazole (CAS: 241479-67-4), bisphenol A (CAS: 80-05-

    In Vitro:

    Article Title: Assessment of the potential risk of oteseconazole and two other tetrazole antifungals to inhibit adrenal steroidogenesis and peripheral metabolism of corticosteroids
    Article Snippet: ymes. In addition, the tetrazoles were subjected to a cell-free 11β-HSD2 activity assay to assess a potential risk of causing pseudohyperaldosteronism. Prochloraz (CAS: 67747-09-5), posaconazole (CAS: 171228-49-2), itraconazole (CAS: 84625-61-6), ketoconazole (CAS: 65277-42-1), fluconazole (CAS: 86386-73-4), voriconazole (CAS: 137234-62-9), isavuconazole (CAS: 241479-67-4), bisphenol A (CAS: 80-05-

    Recombinant:

    Article Title: Assessment of the potential risk of oteseconazole and two other tetrazole antifungals to inhibit adrenal steroidogenesis and peripheral metabolism of corticosteroids
    Article Snippet: ymes. In addition, the tetrazoles were subjected to a cell-free 11β-HSD2 activity assay to assess a potential risk of causing pseudohyperaldosteronism. Prochloraz (CAS: 67747-09-5), posaconazole (CAS: 171228-49-2), itraconazole (CAS: 84625-61-6), ketoconazole (CAS: 65277-42-1), fluconazole (CAS: 86386-73-4), voriconazole (CAS: 137234-62-9), isavuconazole (CAS: 241479-67-4), bisphenol A (CAS: 80-05-

    Activity Assay:

    Article Title: Assessment of the potential risk of oteseconazole and two other tetrazole antifungals to inhibit adrenal steroidogenesis and peripheral metabolism of corticosteroids
    Article Snippet: ymes. In addition, the tetrazoles were subjected to a cell-free 11β-HSD2 activity assay to assess a potential risk of causing pseudohyperaldosteronism. Prochloraz (CAS: 67747-09-5), posaconazole (CAS: 171228-49-2), itraconazole (CAS: 84625-61-6), ketoconazole (CAS: 65277-42-1), fluconazole (CAS: 86386-73-4), voriconazole (CAS: 137234-62-9), isavuconazole (CAS: 241479-67-4), bisphenol A (CAS: 80-05-



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    Image Search Results


    Summary of drug interaction for the combination of BA and azoles. (A) Species–specific summary of interactions between BA–azole combinations and pathogenic fungi. (B) Azole–specific summary of interactions between BA–azole combinations and pathogenic fungi. (C) Isobologram analysis of the synergistic interaction between BA and POS. The X-axis represents normalized POS concentration, and the Y-axis represents normalized BA concentration. Normalized concentration was calculated as the MIC of the drug in combination divided by the MIC of the drug alone. The solid diagonal line represents the theoretical additive effect based on the Loewe additivity model. The upper and lower dashed lines indicate the 95% confidence intervals of the additive line. Each symbol corresponds to a different clinical isolate. Data points located below the lower 95% confidence line indicate synergistic activity. S, synergy (FICI≤0.5); I, indifference (FICI from >0.5 to ≤4); A, antagonism (FICI of >4); BA, betulinic acid; ITR, itraconazole; VOR, voriconazole; POS, posaconazole; FLC, fluconazole. The synergism rate was calculated by dividing the number of strains exhibiting synergism by the total number of strains tested.

    Journal: Frontiers in Microbiology

    Article Title: In vitro synergistic activity of betulinic acid combined with azoles against pathogenic fungi

    doi: 10.3389/fmicb.2026.1835794

    Figure Lengend Snippet: Summary of drug interaction for the combination of BA and azoles. (A) Species–specific summary of interactions between BA–azole combinations and pathogenic fungi. (B) Azole–specific summary of interactions between BA–azole combinations and pathogenic fungi. (C) Isobologram analysis of the synergistic interaction between BA and POS. The X-axis represents normalized POS concentration, and the Y-axis represents normalized BA concentration. Normalized concentration was calculated as the MIC of the drug in combination divided by the MIC of the drug alone. The solid diagonal line represents the theoretical additive effect based on the Loewe additivity model. The upper and lower dashed lines indicate the 95% confidence intervals of the additive line. Each symbol corresponds to a different clinical isolate. Data points located below the lower 95% confidence line indicate synergistic activity. S, synergy (FICI≤0.5); I, indifference (FICI from >0.5 to ≤4); A, antagonism (FICI of >4); BA, betulinic acid; ITR, itraconazole; VOR, voriconazole; POS, posaconazole; FLC, fluconazole. The synergism rate was calculated by dividing the number of strains exhibiting synergism by the total number of strains tested.

    Article Snippet: The experimental drugs, such as ITR (HY–17514, purity = 99.59%), posaconazole (POS, HY–17373, purity = 99.95%) and BA (HY–N1451, purity = 98.77%), were obtained from MedChemExpress (MCE), NJ, USA.

    Techniques: Concentration Assay, Activity Assay

    (A–Q) Detection of ROS levels after combined treatment with BA and POS; (R–U) Detection of ROS levels after combined treatment with BA and ITR. One–way ANOVA followed by Tukey’s HSD test was used for multiple group comparisons. POS, posaconazole; BA, betulinic acid; ns, p > 0.05; * p < 0.05; ** p < 0.01; *** p < 0.001; **** p < 0.0001.

    Journal: Frontiers in Microbiology

    Article Title: In vitro synergistic activity of betulinic acid combined with azoles against pathogenic fungi

    doi: 10.3389/fmicb.2026.1835794

    Figure Lengend Snippet: (A–Q) Detection of ROS levels after combined treatment with BA and POS; (R–U) Detection of ROS levels after combined treatment with BA and ITR. One–way ANOVA followed by Tukey’s HSD test was used for multiple group comparisons. POS, posaconazole; BA, betulinic acid; ns, p > 0.05; * p < 0.05; ** p < 0.01; *** p < 0.001; **** p < 0.0001.

    Article Snippet: The experimental drugs, such as ITR (HY–17514, purity = 99.59%), posaconazole (POS, HY–17373, purity = 99.95%) and BA (HY–N1451, purity = 98.77%), were obtained from MedChemExpress (MCE), NJ, USA.

    Techniques: